Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.010 GeneticVariation disease BEFREE The presence of at least one polymorphic allele for NOS3 T-786C was also associated with the occurrence of eclampsia or HELLP syndrome among preeclamptic women. 26317342 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.030 AlteredExpression disease BEFREE We found that: 1) Placental LEP and FLT1 expression was up-regulated in preterm preeclampsia with or without HELLP syndrome compared to controls; 2) Mean pp38 immunoscore was higher in preterm preeclampsia, especially in cases with HELLP syndrome, than in controls. 25583406 2015
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
0.020 AlteredExpression disease BEFREE We found that: 1) Placental LEP and FLT1 expression was up-regulated in preterm preeclampsia with or without HELLP syndrome compared to controls; 2) Mean pp38 immunoscore was higher in preterm preeclampsia, especially in cases with HELLP syndrome, than in controls. 25583406 2015
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
0.020 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 25897
Gene Symbol: RNF19A
RNF19A
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.010 AlteredExpression disease BEFREE The activation of ERK1/2 signaling may induce additional trophoblastic functional changes in HELLP syndrome, while distinct mechanisms may promote late-onset preeclampsia. 25583406 2015
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 9402
Gene Symbol: GRAP2
GRAP2
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 1398
Gene Symbol: CRK
CRK
0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 966
Gene Symbol: CD59
CD59
0.010 Biomarker disease BEFREE Serum autotaxin was increased in ICP (mean ± SD: 43.5 ± 18.2 nmol ml(-1)min(-1), n=55, p<0.0001) compared to other pruritic disorders of pregnancy (16.8 ± 6.7 nmol ml(-1)min(-1), n=33), pre-eclampsia complicated by HELLP-syndrome (16.8 ± 8.9 nmol ml(-1)min(-1), n=17), and pregnant controls (19.6 ± 5.7 nmol ml(-1)min(-1), n=44). 25450205 2015
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.010 AlteredExpression disease BEFREE ABCG2 expression is reduced in pregnancies where preeclampsia is further complicated by HELLP syndrome. 25446997 2015
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.010 AlteredExpression disease BEFREE CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome. 24612145 2014
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
0.010 AlteredExpression disease BEFREE Since EPHX1 is highly expressed in the liver, can interact with various signaling pathways and is involved in central nervous system disorders, the association of EPHX1 polymorphism with the HELLP syndrome and eclampsia may hint to EPHX being a further key player in the pathogenesis of preeclampsia. 24013430 2014
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.010 AlteredExpression disease BEFREE The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome. 23241952 2013
Entrez Id: 101101692
Gene Symbol: HELLPAR
HELLPAR
0.300 SusceptibilityMutation disease ORPHANET HELLP babies link a novel lincRNA to the trophoblast cell cycle. 23093777 2012
Entrez Id: 5053
Gene Symbol: PAH
PAH
0.010 GeneticVariation disease BEFREE A locus for the HELLP syndrome is present on chromosome 12q23 near PAH. 23093777 2012
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.330 Biomarker disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 GeneticVariation disease ORPHANET The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 Biomarker disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 GeneticVariation disease ORPHANET The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 GeneticVariation disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 629
Gene Symbol: CFB
CFB
0.010 Biomarker disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012